| Bioactivity | KRASG12C IN-2 (compound 17) is an orally active KRASG12C inhibitor. KRASG12C IN-2 inhibits tumor growth in mice[1]. |
| Target | KRASG12C. |
| Invitro | KRASG12C IN-2 (0-100 nM;72 h) 抑制 MIA-PA-CA-2细胞 (KRASG12C 突变) 增殖，IC50 值为 0.44 nM[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | KRASG12C IN-2 (10, 30 mg/kg; p.o.; single daily for 22 days) 抑制小鼠体内肿瘤生长[1]。 Animal Model: |
| Name | KRASG12C IN-2 |
| CAS | 2706637-12-7 |
| Formula | C32H35F6N7O3 |
| Molar Mass | 679.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang Yang, et al. Pyrimidoheterocyclic compounds and application thereof. WO2021180181A1. |